Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

George Dialynas; Om K. Shrestha; Jessica M. Ponce; Monika Zwerger; Dylan A. Thiemann; Grant H. Young; Steven A. Moore; Liping Yu; Jan Lammerding; Lori L. Wallrath

doi:10.1371/journal.pgen.1005231

Loading metrics

Open Access

Peer-reviewed

Research Article

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

George Dialynas ,

Current address: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

¶‡ GD and OKS contributed equally to the research.

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America
⨯
Om K. Shrestha ,

Current address: Department of Biochemistry, University of Wisconsin, Madison, Madison, Wisconsin, United States of America

¶‡ GD and OKS contributed equally to the research.

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jessica M. Ponce,

Affiliation Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, United States of America
⨯
Monika Zwerger,

Current address: Department of Biochemistry, University of Zurich, Zurich, Switzerland

Affiliation Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
⨯
Dylan A. Thiemann,

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America
⨯
Grant H. Young,

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America
⨯
Steven A. Moore,

Affiliation Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Liping Yu,

Affiliations Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America, NMR Facility, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jan Lammerding,

Affiliation Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
⨯
Lori L. Wallrath

* E-mail: lori-wallrath@uiowa.edu

Affiliations Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, United States of America
⨯

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

George Dialynas,
Om K. Shrestha,
Jessica M. Ponce,
Monika Zwerger,
Dylan A. Thiemann,
Grant H. Young,
Steven A. Moore,
Liping Yu,
Jan Lammerding,
Lori L. Wallrath

Published: May 21, 2015
https://doi.org/10.1371/journal.pgen.1005231

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lamins
Is the Subject Area "Lamins" applicable to this article?

Thanks for your feedback.
Drosophila melanogaster
Is the Subject Area "Drosophila melanogaster" applicable to this article?

Thanks for your feedback.
Larvae
Is the Subject Area "Larvae" applicable to this article?

Thanks for your feedback.
Muscle proteins
Is the Subject Area "Muscle proteins" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Muscle tissue
Is the Subject Area "Muscle tissue" applicable to this article?

Thanks for your feedback.
Amino acid substitution
Is the Subject Area "Amino acid substitution" applicable to this article?

Thanks for your feedback.
Muscular dystrophies
Is the Subject Area "Muscular dystrophies" applicable to this article?

Thanks for your feedback.