Cell Specific eQTL Analysis without Sorting Cells

• Harm-Jan Westra ,

  Contributed equally to this work with: Harm-Jan Westra, Danny Arends

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

  ⨯
• Danny Arends ,

  Contributed equally to this work with: Harm-Jan Westra, Danny Arends

  Affiliation Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands

  ⨯
• Tõnu Esko,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

  ⨯
• Marjolein J. Peters,

  Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands, The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/ Rotterdam, the Netherlands

  ⨯
• Claudia Schurmann,

  Affiliations Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Katharina Schramm,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institut für Humangenetik, Technische Universität München, München, Germany

  ⨯
• Johannes Kettunen,

  Affiliations Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland, Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Hanieh Yaghootkar,

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Benjamin P. Fairfax,

  Affiliations Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom

  ⨯
• Anand Kumar Andiappan,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• Yang Li,

  Affiliations University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands

  ⨯
• Jingyuan Fu,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

  ⨯
• Juha Karjalainen,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

  ⨯
• Mathieu Platteel,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

  ⨯
• Marijn Visschedijk,

  Affiliations University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands

  ⨯
• Rinse K. Weersma,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands

  ⨯
• Silva Kasela,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

  ⨯
• Lili Milani,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

  ⨯
• Liina Tserel,

  Affiliation Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

  ⨯
• Pärt Peterson,

  Affiliation Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

  ⨯
• Eva Reinmaa,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

  ⨯
• Albert Hofman,

  Affiliations The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/ Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands, The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/ Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands, The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/ Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands

  ⨯
• Georg Homuth,

  Affiliation Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Astrid Petersmann,

  Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Roberto Lorbeer,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Holger Prokisch,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institut für Humangenetik, Technische Universität München, München, Germany

  ⨯
• Thomas Meitinger,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institut für Humangenetik, Technische Universität München, München, Germany, Munich Heart Alliance, Munich, Germany, German Center for Cardiovascular Research (DZHK), Germany

  ⨯
• Christian Herder,

  Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany

  ⨯
• Michael Roden,

  Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany, Department of Diabetology and Endocrinology, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany

  ⨯
• Harald Grallert,

  Affiliation Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Samuli Ripatti,

  Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland

  ⨯
• Markus Perola,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Andrew R. Wood,

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• David Melzer,

  Affiliation Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom

  ⨯
• Luigi Ferrucci,

  Affiliation Clinical Research Branch, National Institute on Aging NIA-ASTRA Unit, Harbor Hospital, Baltimore, Maryland, United States of America

  ⨯
• Andrew B. Singleton,

  Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Dena G. Hernandez,

  Affiliations Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, London, United Kingdom

  ⨯
• Julian C. Knight,

  Affiliation Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

  ⨯
• Rossella Melchiotti,

  Affiliations Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Doctoral School in Translational and Molecular Medicine (DIMET), University of Milano-Bicocca, Milan, Italy

  ⨯
• Bernett Lee,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• Michael Poidinger,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• Francesca Zolezzi,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• Anis Larbi,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• De Yun Wang,

  Affiliation Department of Otolaryngology, National University of Singapore, Singapore

  ⨯
• Leonard H. van den Berg,

  Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

  ⨯
• Jan H. Veldink,

  Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

  ⨯
• Olaf Rotzschke,

  Affiliation Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

  ⨯
• Seiko Makino,

  Affiliation Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

  ⨯
• Veikko Salomaa,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Konstantin Strauch,

  Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany

  ⨯
• Uwe Völker,

  Affiliation Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Joyce B. J. van Meurs,

  Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands, The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/ Rotterdam, the Netherlands

  ⨯
• Andres Metspalu,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

  ⨯
• Cisca Wijmenga,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

  ⨯
• Ritsert C. Jansen ,

  ¶‡ These authors jointly directed this work.

  Affiliation Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands

  ⨯
•  [ ... ],
• Lude Franke

  * E-mail: lude@ludesign.nl

  ¶‡ These authors jointly directed this work.

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

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