Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Wencheng Li; Bei You; Mainul Hoque; Dinghai Zheng; Wenting Luo; Zhe Ji; Ji Yeon Park; Samuel I. Gunderson; Auinash Kalsotra; James L. Manley; Bin Tian

doi:10.1371/journal.pgen.1005166

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Peer-reviewed

Research Article

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Wencheng Li,

Affiliations Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States of America
⨯
Bei You,

Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Mainul Hoque,

Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Dinghai Zheng,

Affiliations Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States of America
⨯
Wenting Luo,

Affiliations Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Rutgers Graduate School of Biomedical Sciences, Newark, New Jersey, United States of America
⨯
Zhe Ji,

Affiliations Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Rutgers Graduate School of Biomedical Sciences, Newark, New Jersey, United States of America
⨯
Ji Yeon Park,

Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Samuel I. Gunderson,

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Auinash Kalsotra,

Affiliation Departments of Biochemistry and Medical Biochemistry, University of Illinois, Urbana, Illinois, United States of America
⨯
James L. Manley,

Affiliation Department of Biological Sciences, Columbia University, New York, New York, United Staes of America
⨯
Bin Tian

* E-mail: btian@rutgers.edu

Affiliations Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States of America, Rutgers Graduate School of Biomedical Sciences, Newark, New Jersey, United States of America
⨯

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Wencheng Li,
Bei You,
Mainul Hoque,
Dinghai Zheng,
Wenting Luo,
Zhe Ji,
Ji Yeon Park,
Samuel I. Gunderson,
Auinash Kalsotra,
James L. Manley

Published: April 23, 2015
https://doi.org/10.1371/journal.pgen.1005166

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3' UTR
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Gene regulation
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Introns
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Polyadenylation
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Cell differentiation
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