Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

Xiaohu Tang; Melissa M. Keenan; Jianli Wu; Chih-An Lin; Laura Dubois; J. Will Thompson; Stephen J. Freedland; Susan K. Murphy; Jen-Tsan Chi

doi:10.1371/journal.pgen.1005158

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Open Access

Peer-reviewed

Research Article

Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

Xiaohu Tang,

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Melissa M. Keenan,

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jianli Wu,

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Chih-An Lin,

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Laura Dubois,

Affiliations Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Proteomics and Metabolomics Core Facility Duke University Medical Center, Durham, North Carolina, United States of America
⨯
J. Will Thompson,

Affiliations Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Proteomics and Metabolomics Core Facility Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology Duke University Medical Center, Durham, North Carolina, United States of America
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Stephen J. Freedland,

Affiliation Department of Surgery Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Susan K. Murphy,

Affiliation Department of Surgery Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Jen-Tsan Chi

* E-mail: jentsan.chi@duke.edu

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

Xiaohu Tang,
Melissa M. Keenan,
Jianli Wu,
Chih-An Lin,
Laura Dubois,
J. Will Thompson,
Stephen J. Freedland,
Susan K. Murphy,
Jen-Tsan Chi

Published: April 7, 2015
https://doi.org/10.1371/journal.pgen.1005158

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Methionine
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Arginine
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DNA methylation
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Creatine
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Biosynthesis
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Glycine
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Histones
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DNA transcription
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