Male-Biased Aganglionic Megacolon in the TashT Mouse Line Due to Perturbation of Silencer Elements in a Large Gene Desert of Chromosome 10

Karl-F. Bergeron; Tatiana Cardinal; Aboubacrine M. Touré; Mélanie Béland; Diana L. Raiwet; David W. Silversides; Nicolas Pilon

doi:10.1371/journal.pgen.1005093

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Peer-reviewed

Research Article

Male-Biased Aganglionic Megacolon in the TashT Mouse Line Due to Perturbation of Silencer Elements in a Large Gene Desert of Chromosome 10

Karl-F. Bergeron ,

Contributed equally to this work with: Karl-F. Bergeron, Tatiana Cardinal

Affiliation Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal (UQAM), Quebec, Canada
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Tatiana Cardinal ,

Contributed equally to this work with: Karl-F. Bergeron, Tatiana Cardinal

Affiliation Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal (UQAM), Quebec, Canada
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Aboubacrine M. Touré,

Affiliation Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal (UQAM), Quebec, Canada
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Mélanie Béland,

Current address: Molecular Pathology Laboratory, Institute for Research in Immunology and Cancer (IRIC), Quebec, Canada

Affiliation Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal (UQAM), Quebec, Canada
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Diana L. Raiwet,

Affiliation Veterinary Genetics Laboratory, Faculty of Veterinary Medicine, University of Montreal, Quebec, Canada
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David W. Silversides,

Affiliation Veterinary Genetics Laboratory, Faculty of Veterinary Medicine, University of Montreal, Quebec, Canada
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Nicolas Pilon

* E-mail: pilon.nicolas@uqam.ca

Affiliation Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal (UQAM), Quebec, Canada
⨯

Male-Biased Aganglionic Megacolon in the TashT Mouse Line Due to Perturbation of Silencer Elements in a Large Gene Desert of Chromosome 10

Karl-F. Bergeron,
Tatiana Cardinal,
Aboubacrine M. Touré,
Mélanie Béland,
Diana L. Raiwet,
David W. Silversides,
Nicolas Pilon

Published: March 18, 2015
https://doi.org/10.1371/journal.pgen.1005093

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Gastrointestinal tract
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Colon
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Megacolon
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Gene expression
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Yellow fluorescent protein
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Transcription factors
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Genetic loci
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Neuronal differentiation
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