Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics

Diana Raju; Sophie Schonauer; Hussein Hamzeh; Kevin C. Flynn; Frank Bradke; Katharina vom Dorp; Peter Dörmann; Yildiz Yildiz; Christian Trötschel; Ansgar Poetsch; Bernadette Breiden; Konrad Sandhoff; Heinz G. Körschen; Dagmar Wachten

doi:10.1371/journal.pgen.1005063

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Open Access

Peer-reviewed

Research Article

Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics

Diana Raju,

Affiliation Minerva Research Group—Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany
⨯
Sophie Schonauer,

Affiliation Minerva Research Group—Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany
⨯
Hussein Hamzeh,

Affiliation Minerva Research Group—Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany
⨯
Kevin C. Flynn,

Current address: Max-Planck-Institute for Biochemistry, Martinsried, Germany

Affiliation Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE e.V.), Bonn, Germany
⨯
Frank Bradke,

Affiliation Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE e.V.), Bonn, Germany
⨯
Katharina vom Dorp,

Affiliation Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Bonn, Germany
⨯
Peter Dörmann,

Affiliation Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Bonn, Germany
⨯
Yildiz Yildiz,

Affiliation Innere Medizin am Landeskrankenhaus Bregenz, Bregenz, Austria
⨯
Christian Trötschel,

Affiliation Biochemie der Pflanzen, Ruhr-Universität Bochum, Bochum, Germany
⨯
Ansgar Poetsch,

Affiliation Biochemie der Pflanzen, Ruhr-Universität Bochum, Bochum, Germany
⨯
Bernadette Breiden,

Affiliation Life and Medical Sciences Institute (LIMES) c/o Kekulé-Institute of Chemistry and Biochemistry, Bonn, Germany
⨯
Konrad Sandhoff,

Affiliation Life and Medical Sciences Institute (LIMES) c/o Kekulé-Institute of Chemistry and Biochemistry, Bonn, Germany
⨯
Heinz G. Körschen,

Affiliation Department of Molecular Sensory Systems, Center of Advanced European Studies and Research, Bonn, Germany
⨯
Dagmar Wachten

* E-mail: dagmar.wachten@caesar.de

Affiliation Minerva Research Group—Molecular Physiology, Center of Advanced European Studies and Research, Bonn, Germany
⨯

Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics

Diana Raju,
Sophie Schonauer,
Hussein Hamzeh,
Kevin C. Flynn,
Frank Bradke,
Katharina vom Dorp,
Peter Dörmann,
Yildiz Yildiz,
Christian Trötschel,
Ansgar Poetsch

Published: March 24, 2015
https://doi.org/10.1371/journal.pgen.1005063

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