microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes

Rory Blevins; Ludovica Bruno; Thomas Carroll; James Elliott; Antoine Marcais; Christina Loh; Arnulf Hertweck; Azra Krek; Nikolaus Rajewsky; Chang-Zheng Chen; Amanda G. Fisher; Matthias Merkenschlager

doi:10.1371/journal.pgen.1005020

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Peer-reviewed

Research Article

microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes

Rory Blevins,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Ludovica Bruno,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Thomas Carroll,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
James Elliott,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Antoine Marcais,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Christina Loh,

Affiliation Department of Microbiology and Immunology and Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Arnulf Hertweck,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Azra Krek,

Affiliation Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Berlin, Germany
⨯
Nikolaus Rajewsky,

Affiliation Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Berlin, Germany
⨯
Chang-Zheng Chen,

Affiliation Department of Microbiology and Immunology and Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Amanda G. Fisher,

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Matthias Merkenschlager

* E-mail: matthias.merkenschlager@csc.mrc.ac.uk

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯

microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes

Rory Blevins,
Ludovica Bruno,
Thomas Carroll,
James Elliott,
Antoine Marcais,
Christina Loh,
Arnulf Hertweck,
Azra Krek,
Nikolaus Rajewsky,
Chang-Zheng Chen

Published: February 25, 2015
https://doi.org/10.1371/journal.pgen.1005020

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MicroRNAs
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Thymocytes
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Gene expression
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Messenger RNA
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T cells
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3' UTR
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TCR signaling cascade
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Protein expression
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