Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Junghyun Lim; M. Lenard Lachenmayer; Shuai Wu; Wenchao Liu; Mondira Kundu; Rong Wang; Masaaki Komatsu; Young J. Oh; Yanxiang Zhao; Zhenyu Yue

doi:10.1371/journal.pgen.1004987

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Open Access

Peer-reviewed

Research Article

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Junghyun Lim ,

¶‡ These authors contributed equally to this work.

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
M. Lenard Lachenmayer ,

Current address: Department of Neurology, Inselspital, University Hospital Bern, Bern, Switzerland

¶‡ These authors contributed equally to this work.

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Shuai Wu,

Affiliation Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
⨯
Wenchao Liu,

Affiliation Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
⨯
Mondira Kundu,

Affiliation Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Rong Wang,

Affiliation Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Masaaki Komatsu,

Affiliation Department of Biochemistry, Niigata University, Niigata-shi, Japan
⨯
Young J. Oh,

Affiliation Department of System Biology, Yonsei University College of Life Science and Biotechnology, Seoul, South Korea
⨯
Yanxiang Zhao,

Affiliation Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
⨯
Zhenyu Yue

* E-mail: zhenyu.yue@mssm.edu

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Junghyun Lim,
M. Lenard Lachenmayer,
Shuai Wu,
Wenchao Liu,
Mondira Kundu,
Rong Wang,
Masaaki Komatsu,
Young J. Oh,
Yanxiang Zhao,
Zhenyu Yue

Published: February 27, 2015
https://doi.org/10.1371/journal.pgen.1004987

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Phosphorylation
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Autophagic cell death
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Transfection
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Immunoprecipitation
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Protein interactions
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Antibody therapy
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Dimers
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Immunoblotting
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