Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Claire E. Schaar; Dylan J. Dues; Katie K. Spielbauer; Emily Machiela; Jason F. Cooper; Megan Senchuk; Siegfried Hekimi; Jeremy M. Van Raamsdonk

doi:10.1371/journal.pgen.1004972

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Peer-reviewed

Research Article

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Claire E. Schaar ,

¶‡ These authors contributed equally to this work.

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Dylan J. Dues ,

¶‡ These authors contributed equally to this work.

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Katie K. Spielbauer ,

¶‡ These authors contributed equally to this work.

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Emily Machiela,

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Jason F. Cooper,

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Megan Senchuk,

Affiliation Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Siegfried Hekimi,

Affiliation Department of Biology, McGill University, Montreal, Quebec, Canada
⨯
Jeremy M. Van Raamsdonk

* E-mail: jeremy.vanraamsdonk@vai.org

Affiliations Laboratory of Aging and Neurodegenerative Disease (LAND), Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America, Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, Michigan, United States of America, Department of Genetics, Michigan State University, East Lansing, Michigan, United States of America, Department of Biology, McGill University, Montreal, Quebec, Canada
⨯

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Claire E. Schaar,
Dylan J. Dues,
Katie K. Spielbauer,
Emily Machiela,
Jason F. Cooper,
Megan Senchuk,
Siegfried Hekimi,
Jeremy M. Van Raamsdonk

Published: February 11, 2015
https://doi.org/10.1371/journal.pgen.1004972

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