Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Yanhua Yao; Scott Tsuchiyama; Ciyu Yang; Anne Laure Bulteau; Chong He; Brett Robison; Mitsuhiro Tsuchiya; Delana Miller; Valeria Briones; Krisztina Tar; Anahi Potrero; Bertrand Friguet; Brian K. Kennedy; Marion Schmidt

doi:10.1371/journal.pgen.1004968

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Peer-reviewed

Research Article

Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Yanhua Yao ,

¶‡ These authors contributed equally to this work.

Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
⨯
Scott Tsuchiyama ,

¶‡ These authors contributed equally to this work.

Affiliation Buck Institute, Novato, California, United States of America
⨯
Ciyu Yang,

Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
⨯
Anne Laure Bulteau,

Affiliation LCABIE UMR5254, Technopôle Hélioparc Pau Pyrénées, Pau, France
⨯
Chong He,

Affiliation Buck Institute, Novato, California, United States of America
⨯
Brett Robison,

Affiliation Buck Institute, Novato, California, United States of America
⨯
Mitsuhiro Tsuchiya,

Affiliation Buck Institute, Novato, California, United States of America
⨯
Delana Miller,

Affiliation Buck Institute, Novato, California, United States of America
⨯
Valeria Briones,

Affiliation Buck Institute, Novato, California, United States of America
⨯
Krisztina Tar,

Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
⨯
Anahi Potrero,

Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
⨯
Bertrand Friguet,

Affiliation Laboratoire de Biologie Cellulaire du Vieillissement, UR4-IFR83, Université Pierre et Marie Curie-Paris 6, Paris, France
⨯
Brian K. Kennedy ,

* E-mail: marion.schmidt@einstein.yu.edu (MS); bkennedy@buckinstitute.org (BKK)

Affiliation Buck Institute, Novato, California, United States of America
⨯
Marion Schmidt

* E-mail: marion.schmidt@einstein.yu.edu (MS); bkennedy@buckinstitute.org (BKK)

Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
⨯

Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Yanhua Yao,
Scott Tsuchiyama,
Ciyu Yang,
Anne Laure Bulteau,
Chong He,
Brett Robison,
Mitsuhiro Tsuchiya,
Delana Miller,
Valeria Briones,
Krisztina Tar

Published: January 28, 2015
https://doi.org/10.1371/journal.pgen.1004968

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Mitochondria
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Aging
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Cell metabolism
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