African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania

Alphaxard Manjurano; Nuno Sepulveda; Behzad Nadjm; George Mtove; Hannah Wangai; Caroline Maxwell; Raimos Olomi; Hugh Reyburn; Eleanor M. Riley; Christopher J. Drakeley; Taane G. Clark; MalariaGEN Consortium

doi:10.1371/journal.pgen.1004960

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Peer-reviewed

Research Article

African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania

Alphaxard Manjurano,

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
Nuno Sepulveda,

Affiliation Department of Infection and Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Behzad Nadjm,

Current address: Oxford University Clinical Research Unit, Hanoi, Vietnam

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
George Mtove,

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
Hannah Wangai,

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
Caroline Maxwell,

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
Raimos Olomi,

Affiliation Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania
⨯
Hugh Reyburn,

Affiliations Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania, Department of Infection and Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Eleanor M. Riley ,

¶‡ These authors contributed equally to this work.

Affiliations Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania, Department of Infection and Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Christopher J. Drakeley ,

¶‡ These authors contributed equally to this work.

Affiliations Joint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania, Department of Infection and Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Taane G. Clark ,

* E-mail: taane.clark@lshtm.ac.uk

¶‡ These authors contributed equally to this work.

Affiliations Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
MalariaGEN Consortium

¶Membership of the MalariaGen Consortium is listed in the Acknowledgments.

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯

African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania

Alphaxard Manjurano,
Nuno Sepulveda,
Behzad Nadjm,
George Mtove,
Hannah Wangai,
Caroline Maxwell,
Raimos Olomi,
Hugh Reyburn,
Eleanor M. Riley,
Christopher J. Drakeley

Published: February 11, 2015
https://doi.org/10.1371/journal.pgen.1004960

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Malaria
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Single nucleotide polymorphisms
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Glucose-6-phosphate dehydrogenase deficiency
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Heterozygosity
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Haplotypes
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Genetic loci
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Alleles
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Variant genotypes
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