Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

• Daniel D. Lam ,

  Current Address: Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Flavio S. J. de Souza ,

  ¶‡ These authors contributed equally to this work.

  Affiliations Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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• Sofia Nasif,

  Affiliation Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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• Miho Yamashita,

  Current Address: Second Division, Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

  Affiliation Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Rodrigo López-Leal,

  Affiliation Centro de Estudios Científicos, Valdivia, Chile

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• Veronica Otero-Corchon †,

  † Deceased.

  Affiliation Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Kana Meece,

  Affiliation Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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• Harini Sampath,

  Affiliation Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, Oregon, United States of America

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• Aaron J. Mercer,

  Affiliation Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Sharon L. Wardlaw,

  Affiliation Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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• Marcelo Rubinstein ,

  Contributed equally to this work with: Marcelo Rubinstein, Malcolm J. Low

  Affiliations Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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• Malcolm J. Low

  Contributed equally to this work with: Marcelo Rubinstein, Malcolm J. Low

  * E-mail: mjlow@umich.edu

  Affiliation Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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