Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

Prabha Sarangi; Roland Steinacher; Veronika Altmannova; Qiong Fu; Tanya T. Paull; Lumir Krejci; Matthew C. Whitby; Xiaolan Zhao

doi:10.1371/journal.pgen.1004899

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Peer-reviewed

Research Article

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

Prabha Sarangi,

Affiliations Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Programs in Biochemistry, Cell, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, New York, United States of America
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Roland Steinacher,

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
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Veronika Altmannova,

Affiliation Department of Biology, Masaryk University, Brno, Czech Republic
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Qiong Fu,

Affiliation Howard Hughes Medical Institute, Department of Molecular Biosciences, and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
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Tanya T. Paull,

Affiliation Howard Hughes Medical Institute, Department of Molecular Biosciences, and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
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Lumir Krejci,

Affiliations Department of Biology, Masaryk University, Brno, Czech Republic, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital in Brno, Brno, Czech Republic
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Matthew C. Whitby,

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
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Xiaolan Zhao

* E-mail: zhaox1@mskcc.org

Affiliations Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Programs in Biochemistry, Cell, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, New York, United States of America
⨯

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

Prabha Sarangi,
Roland Steinacher,
Veronika Altmannova,
Qiong Fu,
Tanya T. Paull,
Lumir Krejci,
Matthew C. Whitby,
Xiaolan Zhao

Published: January 8, 2015
https://doi.org/10.1371/journal.pgen.1004899

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SUMOylation
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DNA repair
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Phosphorylation
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Non-homologous end joining
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DNA damage
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Solubility
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Southern blot
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Synthesis phase
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