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Open Access
Peer-reviewed
Research Article
Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD
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Seungyeul Yoo,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Sachiko Takikawa,
Affiliation Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
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Patrick Geraghty,
Affiliation Department of Medicine, St. Luke's Roosevelt Medical Center, Mount Sinai School of Medicine, New York, New York, United States of America
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Carmen Argmann,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Joshua Campbell,
Affiliation Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
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Luan Lin,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Tao Huang,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Zhidong Tu,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Robert Feronjy,
Affiliation Department of Medicine, St. Luke's Roosevelt Medical Center, Mount Sinai School of Medicine, New York, New York, United States of America
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Avrum Spira,
Affiliation Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
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Eric E. Schadt,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Charles A. Powell,
Affiliation Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
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Jun Zhu
* E-mail: jun.zhu@mssm.edu
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD
- Seungyeul Yoo,
- Sachiko Takikawa,
- Patrick Geraghty,
- Carmen Argmann,
- Joshua Campbell,
- Luan Lin,
- Tao Huang,
- Zhidong Tu,
- Robert Feronjy,
- Avrum Spira
- Published: January 8, 2015
- https://doi.org/10.1371/journal.pgen.1004898