Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

Jacob C. Ulirsch; Jessica N. Lacy; Xiuli An; Narla Mohandas; Tarjei S. Mikkelsen; Vijay G. Sankaran

doi:10.1371/journal.pgen.1004890

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Peer-reviewed

Research Article

Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

Jacob C. Ulirsch,

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Jessica N. Lacy,

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Xiuli An,

Affiliation New York Blood Center, New York, New York, United States of America
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Narla Mohandas,

Affiliation New York Blood Center, New York, New York, United States of America
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Tarjei S. Mikkelsen,

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America
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Vijay G. Sankaran

* E-mail: sankaran@broadinstitute.org

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

Jacob C. Ulirsch,
Jessica N. Lacy,
Xiuli An,
Narla Mohandas,
Tarjei S. Mikkelsen,
Vijay G. Sankaran

Published: December 18, 2014
https://doi.org/10.1371/journal.pgen.1004890

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