Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

Gerda Saxer; Michael D. Krepps; Eric D. Merkley; Charles Ansong; Brooke L. Deatherage Kaiser; Marie-Thérèse Valovska; Nikola Ristic; Ping T. Yeh; Vittal P. Prakash; Owen P. Leiser; Luay Nakhleh; Henry S. Gibbons; Helen W. Kreuzer; Yousif Shamoo

doi:10.1371/journal.pgen.1004872

Loading metrics

Open Access

Peer-reviewed

Research Article

Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

Gerda Saxer ,

* E-mail: gsaxer@rice.edu (GS); shamoo@rice.edu (YS)

Affiliation Department of BioSciences, Rice University, Houston, Texas, United States of America
⨯
Michael D. Krepps,

Affiliations United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, United States of America, EXCET, Inc, Springfield, Virginia, United States of America
⨯
Eric D. Merkley,

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Charles Ansong,

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Brooke L. Deatherage Kaiser,

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Marie-Thérèse Valovska,

Affiliation Department of BioSciences, Rice University, Houston, Texas, United States of America
⨯
Nikola Ristic,

Affiliation Department of Computer Science, Rice University, Houston, Texas, United States of America
⨯
Ping T. Yeh,

Affiliation Department of BioSciences, Rice University, Houston, Texas, United States of America
⨯
Vittal P. Prakash,

Affiliation Department of BioSciences, Rice University, Houston, Texas, United States of America
⨯
Owen P. Leiser,

Affiliation Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
⨯
Luay Nakhleh,

Affiliation Department of Computer Science, Rice University, Houston, Texas, United States of America
⨯
Henry S. Gibbons,

Affiliation United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, United States of America
⨯
Helen W. Kreuzer,

Affiliation Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Yousif Shamoo

* E-mail: gsaxer@rice.edu (GS); shamoo@rice.edu (YS)

Affiliation Department of BioSciences, Rice University, Houston, Texas, United States of America
⨯

Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

Gerda Saxer,
Michael D. Krepps,
Eric D. Merkley,
Charles Ansong,
Brooke L. Deatherage Kaiser,
Marie-Thérèse Valovska,
Nikola Ristic,
Ping T. Yeh,
Vittal P. Prakash,
Owen P. Leiser

Published: December 11, 2014
https://doi.org/10.1371/journal.pgen.1004872

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Evolutionary adaptation
Is the Subject Area "Evolutionary adaptation" applicable to this article?

Thanks for your feedback.
Insertion mutation
Is the Subject Area "Insertion mutation" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Regulator genes
Is the Subject Area "Regulator genes" applicable to this article?

Thanks for your feedback.
Deletion mutation
Is the Subject Area "Deletion mutation" applicable to this article?

Thanks for your feedback.
Population genetics
Is the Subject Area "Population genetics" applicable to this article?

Thanks for your feedback.
Proteomics
Is the Subject Area "Proteomics" applicable to this article?

Thanks for your feedback.
Substitution mutation
Is the Subject Area "Substitution mutation" applicable to this article?

Thanks for your feedback.