Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Kahori Shiba-Fukushima; Taku Arano; Gen Matsumoto; Tsuyoshi Inoshita; Shigeharu Yoshida; Yasushi Ishihama; Kwon-Yul Ryu; Nobuyuki Nukina; Nobutaka Hattori; Yuzuru Imai

doi:10.1371/journal.pgen.1004861

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Open Access

Peer-reviewed

Research Article

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Kahori Shiba-Fukushima,

Affiliation Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Taku Arano,

Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Gen Matsumoto,

Affiliation Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Tsuyoshi Inoshita,

Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Shigeharu Yoshida,

Affiliation Department of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Yasushi Ishihama,

Affiliation Department of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Kwon-Yul Ryu,

Affiliation Department of Life Science, University of Seoul, Seoul, Korea
⨯
Nobuyuki Nukina,

Affiliation Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Nobutaka Hattori ,

* E-mail: nhattori@juntendo.ac.jp (NH); yzimai@juntendo.ac.jp (YIm)

Affiliations Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan, Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Yuzuru Imai

* E-mail: nhattori@juntendo.ac.jp (NH); yzimai@juntendo.ac.jp (YIm)

Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Kahori Shiba-Fukushima,
Taku Arano,
Gen Matsumoto,
Tsuyoshi Inoshita,
Shigeharu Yoshida,
Yasushi Ishihama,
Kwon-Yul Ryu,
Nobuyuki Nukina,
Nobutaka Hattori,
Yuzuru Imai

Published: December 4, 2014
https://doi.org/10.1371/journal.pgen.1004861

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26 Jan 2015
16:21 GMT
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Linked Perspective article. Posted by PLOS_Genetics on 26 Jan 2015 at 16:21 GMT

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