Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

• Rui Gao,

  Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Yongping Liu,

  Current address: Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China

  Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Anabela Silva-Fernandes,

  Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s PT Government Associate Laboratory, Braga/Guimarặes, Portugal

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• Xiang Fang,

  Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Adriana Paulucci-Holthauzen,

  Affiliation Department of Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Arpita Chatterjee,

  Affiliation Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Hang L. Zhang,

  Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Tohru Matsuura,

  Affiliation Department of Neurology, Jichi Medical School, Shimotsuke, Japan

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• Sanjeev Choudhary,

  Affiliation Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Tetsuo Ashizawa,

  Affiliation Department of Neurology and McNight Brain Research Institute, University of Florida, Gainesville, Florida, United States of America

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• Arnulf H. Koeppen,

  Affiliation Department of Neurology, Albany Stratton VA Medical Center, Albany, New York, United States of America

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• Patricia Maciel,

  Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s PT Government Associate Laboratory, Braga/Guimarặes, Portugal

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• Tapas K. Hazra,

  Affiliation Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Partha S. Sarkar

  * E-mail: pssarkar@utmb.edu

  Affiliations Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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