24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex

Andrew S. P. Lim; Gyan P. Srivastava; Lei Yu; Lori B. Chibnik; Jishu Xu; Aron S. Buchman; Julie A. Schneider; Amanda J. Myers; David A. Bennett; Philip L. De Jager

doi:10.1371/journal.pgen.1004792

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Open Access

Peer-reviewed

Research Article

24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex

Andrew S. P. Lim ,

* E-mail: andrew.lim@utoronto.ca

Affiliation Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
⨯
Gyan P. Srivastava,

Affiliations Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
⨯
Lei Yu,

Affiliation Rush Alzheimer Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
⨯
Lori B. Chibnik,

Affiliations Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
⨯
Jishu Xu,

Affiliations Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
⨯
Aron S. Buchman,

Affiliation Rush Alzheimer Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
⨯
Julie A. Schneider,

Affiliation Rush Alzheimer Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
⨯
Amanda J. Myers,

Affiliation Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
David A. Bennett,

Affiliation Rush Alzheimer Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
⨯
Philip L. De Jager

Affiliations Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
⨯

24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex

Andrew S. P. Lim,
Gyan P. Srivastava,
Lei Yu,
Lori B. Chibnik,
Jishu Xu,
Aron S. Buchman,
Julie A. Schneider,
Amanda J. Myers,
David A. Bennett,
Philip L. De Jager

Published: November 6, 2014
https://doi.org/10.1371/journal.pgen.1004792

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DNA methylation
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DNA transcription
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Circadian rhythms
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Alzheimer's disease
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Gene expression
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Prefrontal cortex
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Introns
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RNA sequencing
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