The Analysis of Mutant Alleles of Different Strength Reveals Multiple Functions of Topoisomerase 2 in Regulation of Drosophila Chromosome Structure

Valentina Mengoli; Elisabetta Bucciarelli; Ramona Lattao; Roberto Piergentili; Maurizio Gatti; Silvia Bonaccorsi

doi:10.1371/journal.pgen.1004739

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Research Article

The Analysis of Mutant Alleles of Different Strength Reveals Multiple Functions of Topoisomerase 2 in Regulation of Drosophila Chromosome Structure

Valentina Mengoli ,

Contributed equally to this work with: Valentina Mengoli, Elisabetta Bucciarelli

Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy
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Elisabetta Bucciarelli ,

Contributed equally to this work with: Valentina Mengoli, Elisabetta Bucciarelli

Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy
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Ramona Lattao,

Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy
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Roberto Piergentili,

Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy
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Maurizio Gatti ,

* E-mail: maurizio.gatti@uniroma1.it (MG); silvia.bonaccorsi@uniroma1.it (SB)

Affiliations Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia
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Silvia Bonaccorsi

* E-mail: maurizio.gatti@uniroma1.it (MG); silvia.bonaccorsi@uniroma1.it (SB)

Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari (IBPM) del CNR, Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza, Università di Roma, Roma, Italy
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The Analysis of Mutant Alleles of Different Strength Reveals Multiple Functions of Topoisomerase 2 in Regulation of Drosophila Chromosome Structure

Valentina Mengoli,
Elisabetta Bucciarelli,
Ramona Lattao,
Roberto Piergentili,
Maurizio Gatti,
Silvia Bonaccorsi

Published: October 23, 2014
https://doi.org/10.1371/journal.pgen.1004739

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Chromatin
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Spermatocytes
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Drosophila melanogaster
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Chromosome structure and function
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Chromatids
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Heterochromatin
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