Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

Anders H. Olsson; Petr Volkov; Karl Bacos; Tasnim Dayeh; Elin Hall; Emma A. Nilsson; Claes Ladenvall; Tina Rönn; Charlotte Ling

doi:10.1371/journal.pgen.1004735

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Open Access

Peer-reviewed

Research Article

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

Anders H. Olsson,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Petr Volkov,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Karl Bacos,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Tasnim Dayeh,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Elin Hall,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Emma A. Nilsson,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Claes Ladenvall,

Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Tina Rönn,

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯
Charlotte Ling

* E-mail: charlotte.ling@med.lu.se

Affiliation Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmö, Sweden
⨯

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

Anders H. Olsson,
Petr Volkov,
Karl Bacos,
Tasnim Dayeh,
Elin Hall,
Emma A. Nilsson,
Claes Ladenvall,
Tina Rönn,
Charlotte Ling

Published: November 6, 2014
https://doi.org/10.1371/journal.pgen.1004735

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DNA methylation
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Single nucleotide polymorphisms
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Diabetes mellitus
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Gene expression
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Insulin secretion
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Messenger RNA
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Genome-wide association studies
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Human genomics
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