Identification of Rare Causal Variants in Sequence-Based Studies: Methods and Applications to VPS13B, a Gene Involved in Cohen Syndrome and Autism

• Iuliana Ionita-Laza ,

  Contributed equally to this work with: Iuliana Ionita-Laza, Marinela Capanu

  * E-mail: ii2135@columbia.edu

  Affiliation Department of Biostatistics, Columbia University, New York, New York, United States of America

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• Marinela Capanu ,

  Contributed equally to this work with: Iuliana Ionita-Laza, Marinela Capanu

  Affiliation Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Silvia De Rubeis,

  Affiliations Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Departments of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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• Kenneth McCallum,

  Affiliation Department of Biostatistics, Columbia University, New York, New York, United States of America

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• Joseph D. Buxbaum

  Affiliations Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Departments of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America, Departments of Genetics and Genomic Sciences, and Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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