FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs

Sung-Suk Suh; Ji Young Yoo; Ri Cui; Balveen Kaur; Kay Huebner; Taek-Kyun Lee; Rami I. Aqeilan; Carlo M. Croce

doi:10.1371/journal.pgen.1004652

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Open Access

Peer-reviewed

Research Article

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs

Sung-Suk Suh,

Affiliations Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America, South Sea Environmental Research Division, Korea Institute of Ocean Science and Technology, Geoje, South Korea
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Ji Young Yoo,

Affiliation Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio, United States of America
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Ri Cui,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
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Balveen Kaur,

Affiliation Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio, United States of America
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Kay Huebner,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
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Taek-Kyun Lee,

Affiliation South Sea Environmental Research Division, Korea Institute of Ocean Science and Technology, Geoje, South Korea
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Rami I. Aqeilan,

Affiliations Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America, The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Carlo M. Croce

* E-mail: Carlo.Croce@osumc.edu

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs

Sung-Suk Suh,
Ji Young Yoo,
Ri Cui,
Balveen Kaur,
Kay Huebner,
Taek-Kyun Lee,
Rami I. Aqeilan,
Carlo M. Croce

Published: October 23, 2014
https://doi.org/10.1371/journal.pgen.1004652

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Lung and intrathoracic tumors
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MicroRNAs
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Gene expression
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