Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

Sofía Feliziani; Rasmus L. Marvig; Adela M. Luján; Alejandro J. Moyano; Julio A. Di Rienzo; Helle Krogh Johansen; Søren Molin; Andrea M. Smania

doi:10.1371/journal.pgen.1004651

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Peer-reviewed

Research Article

Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

Sofía Feliziani,

Affiliation Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
⨯
Rasmus L. Marvig ,

Contributed equally to this work with: Rasmus L. Marvig, Adela M. Luján

Affiliation Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Adela M. Luján ,

Contributed equally to this work with: Rasmus L. Marvig, Adela M. Luján

Affiliations Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina, Daphne du Maurier, Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Cornwall, United Kingdom
⨯
Alejandro J. Moyano,

Affiliation Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
⨯
Julio A. Di Rienzo,

Affiliation Estadística y Biometría, Facultad de Ciencias Agropecuarias, Universidad Nacional de Córdoba, Córdoba, Argentina
⨯
Helle Krogh Johansen,

Affiliation Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen University Hospital, Copenhagen, and The Novo Nordisk Foundation Centre for Biosustainability, Hørsholm, Technical University of Denmark, Denmark
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Søren Molin,

Affiliation Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Andrea M. Smania

* E-mail: asmania@fcq.unc.edu.ar

Affiliation Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
⨯

Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

Sofía Feliziani,
Rasmus L. Marvig,
Adela M. Luján,
Alejandro J. Moyano,
Julio A. Di Rienzo,
Helle Krogh Johansen,
Søren Molin,
Andrea M. Smania

Published: October 16, 2014
https://doi.org/10.1371/journal.pgen.1004651

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Pseudomonas aeruginosa
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Mutation
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Single nucleotide polymorphisms
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