The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

• Ya-Juan Wang ,

  * E-mail: yajuan.wang@case.edu (YJW); xiaofeng.zhu@case.edu (XZ)

  Affiliations Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Bamidele O. Tayo,

  Affiliation Department of Public Health Sciences, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America

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• Anupam Bandyopadhyay,

  Affiliation Department of Chemistry, Boston College, Chestnut Hill, Massachusetts, United States of America

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• Heming Wang,

  Affiliation Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Tao Feng,

  Affiliation Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Nora Franceschini,

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Hua Tang,

  Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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• Jianmin Gao,

  Affiliation Department of Chemistry, Boston College, Chestnut Hill, Massachusetts, United States of America

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• Yun Ju Sung,

  Affiliation Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, United States of America

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• the COGENT BP consortium ,

  ¶Full membership of the COGENT BP consortium is provided in the acknowledgments.

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• Robert C. Elston,

  Affiliation Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Scott M. Williams,

  Affiliation Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America

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• Richard S. Cooper,

  Affiliation Department of Public Health Sciences, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America

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• Ting-Wei Mu,

  Affiliation Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Xiaofeng Zhu

  * E-mail: yajuan.wang@case.edu (YJW); xiaofeng.zhu@case.edu (XZ)

  Affiliation Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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