tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Mayumi Okamoto; Mamoru Fujiwara; Masato Hori; Kaoru Okada; Futoshi Yazama; Hiroaki Konishi; Yegui Xiao; Guangying Qi; Fumio Shimamoto; Takahide Ota; Achim Temme; Masaaki Tatsuka

doi:10.1371/journal.pgen.1004639

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Open Access

Peer-reviewed

Research Article

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Mayumi Okamoto ,

Contributed equally to this work with: Mayumi Okamoto, Mamoru Fujiwara

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Mamoru Fujiwara ,

Contributed equally to this work with: Mayumi Okamoto, Mamoru Fujiwara

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Masato Hori,

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Kaoru Okada,

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Futoshi Yazama,

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Hiroaki Konishi,

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯
Yegui Xiao,

Affiliation Department of Management Information Systems, Faculty of Management and Information System, Prefectural University of Hiroshima, Minami-ku, Hiroshima, Japan
⨯
Guangying Qi,

Affiliation Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Minami-ku, Hiroshima, Japan
⨯
Fumio Shimamoto,

Affiliation Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Minami-ku, Hiroshima, Japan
⨯
Takahide Ota,

Affiliation Department of Life Science, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan
⨯
Achim Temme,

Affiliation Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⨯
Masaaki Tatsuka

* E-mail: tatsuka@pu-hiroshima.ac.jp

Affiliation Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shoubara, Hiroshima, Japan
⨯

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Mayumi Okamoto,
Mamoru Fujiwara,
Masato Hori,
Kaoru Okada,
Futoshi Yazama,
Hiroaki Konishi,
Yegui Xiao,
Guangying Qi,
Fumio Shimamoto,
Takahide Ota

Published: September 18, 2014
https://doi.org/10.1371/journal.pgen.1004639

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