Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Nicole C. McKnight; Yun Zhong; Mitchell S. Wold; Shiaoching Gong; Greg R. Phillips; Zhixun Dou; Yanxiang Zhao; Nathaniel Heintz; Wei-Xing Zong; Zhenyu Yue

doi:10.1371/journal.pgen.1004626

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Peer-reviewed

Research Article

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Nicole C. McKnight ,

Contributed equally to this work with: Nicole C. McKnight, Yun Zhong

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Yun Zhong ,

Contributed equally to this work with: Nicole C. McKnight, Yun Zhong

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Mitchell S. Wold,

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Shiaoching Gong,

Affiliation Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America
⨯
Greg R. Phillips,

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Zhixun Dou,

Affiliation Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Yanxiang Zhao,

Affiliation Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
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Nathaniel Heintz,

Affiliation Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York, United States of America
⨯
Wei-Xing Zong,

Affiliation Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Zhenyu Yue

* E-mail: zhenyu.yue@mssm.edu

Affiliation Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Nicole C. McKnight,
Yun Zhong,
Mitchell S. Wold,
Shiaoching Gong,
Greg R. Phillips,
Zhixun Dou,
Yanxiang Zhao,
Nathaniel Heintz,
Wei-Xing Zong,
Zhenyu Yue

Published: October 2, 2014
https://doi.org/10.1371/journal.pgen.1004626

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