Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Laura C. Greaves; Marco Nooteboom; Joanna L. Elson; Helen A. L. Tuppen; Geoffrey A. Taylor; Daniel M. Commane; Ramesh P. Arasaradnam; Konstantin Khrapko; Robert W. Taylor; Thomas B. L. Kirkwood; John C. Mathers; Douglass M. Turnbull

doi:10.1371/journal.pgen.1004620

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Open Access

Peer-reviewed

Research Article

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Laura C. Greaves ,

* E-mail: laura.greaves@ncl.ac.uk

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Marco Nooteboom,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Joanna L. Elson,

Affiliations Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa
⨯
Helen A. L. Tuppen,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Geoffrey A. Taylor,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Daniel M. Commane,

Affiliation Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Ramesh P. Arasaradnam,

Affiliation Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Konstantin Khrapko,

Affiliation Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Robert W. Taylor,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Thomas B. L. Kirkwood,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
John C. Mathers,

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Douglass M. Turnbull

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Laura C. Greaves,
Marco Nooteboom,
Joanna L. Elson,
Helen A. L. Tuppen,
Geoffrey A. Taylor,
Daniel M. Commane,
Ramesh P. Arasaradnam,
Konstantin Khrapko,
Robert W. Taylor,
Thomas B. L. Kirkwood

Published: September 18, 2014
https://doi.org/10.1371/journal.pgen.1004620

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Mitochondrial DNA
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Point mutation
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Mutation detection
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Colon
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Epithelium
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