Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

Erik Södersten; Michael Feyder; Mads Lerdrup; Ana-Luisa Gomes; Hanna Kryh; Giada Spigolon; Jocelyne Caboche; Gilberto Fisone; Klaus Hansen

doi:10.1371/journal.pgen.1004574

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Open Access

Peer-reviewed

Research Article

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

Erik Södersten ,

Contributed equally to this work with: Erik Södersten, Michael Feyder

Affiliations Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Michael Feyder ,

Contributed equally to this work with: Erik Södersten, Michael Feyder

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Mads Lerdrup,

Affiliation Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
⨯
Ana-Luisa Gomes,

Affiliation Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
⨯
Hanna Kryh,

Affiliation Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
⨯
Giada Spigolon,

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Jocelyne Caboche,

Affiliation INSERM, U952, CNRS UMR 7224, Université Pierre et Marie Curie, Paris 06, Paris, France
⨯
Gilberto Fisone ,

* E-mail: gilberto.fisone@ki.se (GF); klaus.hansen@bric.ku.dk (KH)

Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Klaus Hansen

* E-mail: gilberto.fisone@ki.se (GF); klaus.hansen@bric.ku.dk (KH)

Affiliation Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
⨯

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

Erik Södersten,
Michael Feyder,
Mads Lerdrup,
Ana-Luisa Gomes,
Hanna Kryh,
Giada Spigolon,
Jocelyne Caboche,
Gilberto Fisone,
Klaus Hansen

Published: September 25, 2014
https://doi.org/10.1371/journal.pgen.1004574

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