Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

• Relja Popovic ,

  Contributed equally to this work with: Relja Popovic, Eva Martinez-Garcia

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Eva Martinez-Garcia ,

  Contributed equally to this work with: Relja Popovic, Eva Martinez-Garcia

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Eugenia G. Giannopoulou,

  Affiliations Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, United States of America, Biological Sciences Department, New York City College of Technology, City University of New York, Brooklyn, New York, New York, United States of America

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• Quanwei Zhang,

  Affiliation Department of Statistics, Northwestern University, Evanston, Illinois, United States of America

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• Qingyang Zhang,

  Affiliation Department of Statistics, Northwestern University, Evanston, Illinois, United States of America

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• Teresa Ezponda,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Mrinal Y. Shah,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Yupeng Zheng,

  Affiliation Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

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• Christine M. Will,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Eliza C. Small,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Youjia Hua,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Marinka Bulic,

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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• Yanwen Jiang,

  Affiliation HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America

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• Matteo Carrara,

  Affiliation Molecular Biotechnology Center, Department of Biotechnology and Health Sciences, University of Torino, Torino, Italy

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• Raffaele A. Calogero,

  Affiliation Molecular Biotechnology Center, Department of Biotechnology and Health Sciences, University of Torino, Torino, Italy

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• William L. Kath,

  Affiliation Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America

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• Neil L. Kelleher,

  Affiliation Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America

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• Ji-Ping Wang,

  Affiliation Department of Statistics, Northwestern University, Evanston, Illinois, United States of America

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• Olivier Elemento,

  Affiliation HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America

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•  [ ... ],
• Jonathan D. Licht

  * E-mail: j-licht@northwestern.edu

  Affiliation Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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