Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

• Ville-Petteri Mäkinen,

  Affiliations Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia

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• Mete Civelek,

  Affiliation Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America

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• Qingying Meng,

  Affiliation Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America

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• Bin Zhang,

  Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Jun Zhu,

  Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Candace Levian,

  Affiliation Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America

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• Tianxiao Huan,

  Affiliation National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

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• Ayellet V. Segrè,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Sujoy Ghosh,

  Affiliations Department of Cardiovascular and Metabolic Research, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, United States of America, Program in Cardiovascular and Metabolic Disorders and Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore

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• Juan Vivar,

  Affiliation Department of Cardiovascular and Metabolic Research, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, United States of America

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• Majid Nikpay,

  Affiliation Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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• Alexandre F. R. Stewart,

  Affiliation John and Jennifer Ruddy Canadian Cardiovascular Research Center, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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• Christopher P. Nelson,

  Affiliations Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

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• Christina Willenborg,

  Affiliation Institut für Integrative und Experimentelle Genomik, University of Lübeck, Lübeck, Germany

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• Jeanette Erdmann,

  Affiliations Institut für Integrative und Experimentelle Genomik, University of Lübeck, Lübeck, Germany, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg, Kiel, Lübeck, Germany

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• Stefan Blakenberg,

  Affiliation Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany

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• Christopher J. O'Donnell,

  Affiliations National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiology Division, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Winfried März,

  Affiliations Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany, Synlab Academy, Mannheim, Germany

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• Reijo Laaksonen,

  Affiliation Science Center, Tampere University Hospital, Tampere, Finland

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• Stephen E. Epstein,

  Affiliation Cardiovascular Research Institute, Washington Hospital Center, Washington, D.C., United States of America

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• Sekar Kathiresan,

  Affiliations National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiology Division, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Svati H. Shah,

  Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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• Stanley L. Hazen,

  Affiliation Cleveland Clinic, Cleveland, Ohio, United States of America

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• Muredach P. Reilly,

  Affiliation Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium ,

  ¶Membership of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium is provided in the Acknowledgments.

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• Aldons J. Lusis,

  Affiliation Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America

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• Nilesh J. Samani,

  Affiliations Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

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• Heribert Schunkert,

  Affiliations DZHK (German Research Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany

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• Thomas Quertermous,

  Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

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• Ruth McPherson,

  Affiliation Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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• Xia Yang ,

  * E-mail: xyang123@ucla.edu (XY); tassimes@stanford.edu (TLA)

  Affiliation Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America

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•  [ ... ],
• Themistocles L. Assimes

  * E-mail: xyang123@ucla.edu (XY); tassimes@stanford.edu (TLA)

  Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

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