Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

• Jennifer L. Bolton ,

  Contributed equally to this work with: Jennifer L. Bolton, Caroline Hayward

  Affiliation University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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• Caroline Hayward ,

  Contributed equally to this work with: Jennifer L. Bolton, Caroline Hayward

  Affiliation MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Nese Direk,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

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• John G. Lewis,

  Affiliation Canterbury Health Laboratories, Christchurch, New Zealand

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• Geoffrey L. Hammond,

  Affiliation Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada

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• Lesley A. Hill,

  Affiliation Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada

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• Anna Anderson,

  Affiliation University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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• Jennifer Huffman,

  Affiliation MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• James F. Wilson,

  Affiliation Centre for Population Health Sciences, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Harry Campbell,

  Affiliation Centre for Population Health Sciences, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Igor Rudan,

  Affiliation Centre for Population Health Sciences, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Alan Wright,

  Affiliation MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Nicholas Hastie,

  Affiliation MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Sarah H. Wild,

  Affiliation Centre for Population Health Sciences, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Fleur P. Velders,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

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• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

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• Andre G. Uitterlinden,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

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• Jari Lahti,

  Affiliation Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

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• Katri Räikkönen,

  Affiliation Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

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• Eero Kajantie,

  Affiliation National Institute for Health and Welfare, Helsinki, Finland

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• Elisabeth Widen,

  Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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• Aarno Palotie,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

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• Johan G. Eriksson,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland, Folkhalsan Research Centre, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland

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• Marika Kaakinen,

  Affiliation Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland

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• Marjo-Riitta Järvelin,

  Affiliations Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom, Unit of Primary Care, Oulu University Hospital, Oulu, Finland

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• Nicholas J. Timpson,

  Affiliation MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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• George Davey Smith,

  Affiliation MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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• Susan M. Ring,

  Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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• David M. Evans,

  Affiliation MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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• Beate St Pourcain,

  Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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• Toshiko Tanaka,

  Affiliation Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America

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• Yuri Milaneschi,

  Affiliations Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America, Department of Psychiatry, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands

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• Stefania Bandinelli,

  Affiliation Geriatric Unit, ASF, Florence, Italy

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• Luigi Ferrucci,

  Affiliation Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America

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• Pim van der Harst,

  Affiliations University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands

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• Judith G. M. Rosmalen,

  Affiliation University of Groningen, University Medical Center Groningen, Interdisciplinary Center for Psychiatric Epidemiology, Groningen, The Netherlands

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• Stephen J. L. Bakker,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, The Netherlands

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• Niek Verweij,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands

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• Robin P. F. Dullaart,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, The Netherlands

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• Anubha Mahajan,

  Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Cecilia M. Lindgren,

  Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Andrew Morris,

  Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Lars Lind,

  Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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• Erik Ingelsson,

  Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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• Laura N. Anderson,

  Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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• Craig E. Pennell,

  Affiliation School of Women's and Infant's Health, The University of Western Australia, Crawley, Australia

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• Stephen J. Lye,

  Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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• Stephen G. Matthews,

  Affiliation Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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• Joel Eriksson,

  Affiliation Center for Bone and Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Dan Mellstrom,

  Affiliation Center for Bone and Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Claes Ohlsson,

  Affiliation Center for Bone and Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Jackie F. Price,

  Affiliation Centre for Population Health Sciences, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Mark W. J. Strachan,

  Affiliation University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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• Rebecca M. Reynolds,

  Affiliation University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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• Henning Tiemeier,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

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• Brian R. Walker ,

  * E-mail: b.walker@ed.ac.uk

  Affiliation University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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•  [ ... ],
• on behalf of the CORtisol NETwork (CORNET) Consortium
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