A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

• Matthew Traylor ,

  * E-mail: mtraylor@sgul.ac.uk

  Affiliation Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom

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• Kari-Matti Mäkelä,

  Affiliations Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

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• Laura L. Kilarski,

  Affiliation Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom

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• Elizabeth G. Holliday,

  Affiliations Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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• William J. Devan,

  Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Mike A. Nalls,

  Affiliation Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

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• Kerri L. Wiggins,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Wei Zhao,

  Affiliation Perelman School of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Yu-Ching Cheng,

  Affiliations Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Research and Development Program, Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States of America

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• Sefanja Achterberg,

  Affiliation Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

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• Rainer Malik,

  Affiliation Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany

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• Cathie Sudlow,

  Affiliation Division of Clinical Neurosciences and Insititute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Steve Bevan,

  Affiliation Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

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• Emma Raitoharju,

  Affiliations Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

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• METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) ,

  ¶Members of Wellcome Trust Case Consortium 2 are listed in the Text S1.

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• Niku Oksala,

  Affiliations Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland, Department of Surgery, Tampere University Hospital, Tampere, Finland

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• Vincent Thijs,

  Affiliations KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology - Laboratory of Neurobiology, Leuven, Belgium, VIB - Vesalius Research Center, Leuven, Belgium, University Hospitals Leuven, Department of Neurology, Leuven, Belgium

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• Robin Lemmens,

  Affiliations KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology - Laboratory of Neurobiology, Leuven, Belgium, VIB - Vesalius Research Center, Leuven, Belgium, University Hospitals Leuven, Department of Neurology, Leuven, Belgium

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• Arne Lindgren,

  Affiliations Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden, Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden

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• Agnieszka Slowik,

  Affiliation Department of Neurology, Jagiellonian University, Krakow, Poland

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• Jane M. Maguire,

  Affiliations Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, School of Nursing and Midwifery, University of Newcastle, Callaghan, New South Wales, Australia, Centre for Translational Neuroscience and Mental Health, University of Newcastle, Callaghan, New South Wales, Australia

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• Matthew Walters,

  Affiliation Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

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• Ale Algra,

  Affiliations Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

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• Pankaj Sharma,

  Affiliation Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, London, United Kingdom

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• John R. Attia,

  Affiliations Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, Centre for Translational Neuroscience and Mental Health, University of Newcastle, Callaghan, New South Wales, Australia

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• Giorgio B. Boncoraglio,

  Affiliation Department of Cereberovascular Disease, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Neurologico Carlo Besta, Milan, Italy

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• Peter M. Rothwell,

  Affiliation Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom

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• Paul I. W. de Bakker,

  Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Centre, Utrecht, The Netherlands, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Joshua C. Bis,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Danish Saleheen,

  Affiliations Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Non-Communicable Diseases, Karachi, Pakistan

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• Steven J. Kittner,

  Affiliation Research and Development Program, Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States of America

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• Braxton D. Mitchell,

  Affiliation Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• Jonathan Rosand,

  Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• James F. Meschia,

  Affiliation Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

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• Christopher Levi,

  Affiliations Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, Centre for Translational Neuroscience and Mental Health, University of Newcastle, Callaghan, New South Wales, Australia

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• Martin Dichgans,

  Affiliations Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität, Munich, Germany

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• Terho Lehtimäki,

  Affiliations Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, School of Medicine, University of Tampere, Tampere, Finland

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• Cathryn M. Lewis ,

  Contributed equally to this work with: Cathryn M. Lewis, Hugh S. Markus

  Affiliations Department of Medical & Molecular Genetics, King's College London, London, United Kingdom, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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•  [ ... ],
• Hugh S. Markus

  Contributed equally to this work with: Cathryn M. Lewis, Hugh S. Markus

  Affiliation Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

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