Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

Jessica Hopkins; Grace Hwang; Justin Jacob; Nicklas Sapp; Rick Bedigian; Kazuhiro Oka; Paul Overbeek; Steve Murray; Philip W. Jordan

doi:10.1371/journal.pgen.1004413

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Research Article

Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

Jessica Hopkins,

Affiliation Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Grace Hwang ,

Contributed equally to this work with: Grace Hwang, Justin Jacob, Nicklas Sapp

Affiliation Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Justin Jacob ,

Contributed equally to this work with: Grace Hwang, Justin Jacob, Nicklas Sapp

Affiliation Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Nicklas Sapp ,

Contributed equally to this work with: Grace Hwang, Justin Jacob, Nicklas Sapp

Affiliation Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Rick Bedigian,

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Kazuhiro Oka,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Paul Overbeek,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Steve Murray,

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Philip W. Jordan

* E-mail: pjordan8@jhu.edu

Affiliation Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯

Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

Jessica Hopkins,
Grace Hwang,
Justin Jacob,
Nicklas Sapp,
Rick Bedigian,
Kazuhiro Oka,
Paul Overbeek,
Steve Murray,
Philip W. Jordan

Published: July 3, 2014
https://doi.org/10.1371/journal.pgen.1004413

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Chromatin
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Chromatids
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Germ cells
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Meiosis
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Centromeres
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DNA-binding proteins
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DNA repair
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