Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

• Harry F. Heijnen ,

  Contributed equally to this work with: Harry F. Heijnen, Richard van Wijk

  Affiliations Cell Microscopy Center, Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Richard van Wijk ,

  Contributed equally to this work with: Harry F. Heijnen, Richard van Wijk

  Affiliation Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Tamara C. Pereboom ,

  ¶TCP and YJG also contributed equally to this work.

  Affiliation Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands

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• Yvonne J. Goos ,

  ¶TCP and YJG also contributed equally to this work.

  Affiliation Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands

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• Cor W. Seinen,

  Affiliations Cell Microscopy Center, Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Brigitte A. van Oirschot,

  Affiliation Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Rowie van Dooren,

  Affiliation Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands

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• Marc Gastou,

  Affiliation U1009, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France

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• Rachel H. Giles,

  Affiliation Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Wouter van Solinge,

  Affiliation Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Taco W. Kuijpers,

  Affiliation Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center (AMC), Amsterdam, The Netherlands

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• Hanna T. Gazda,

  Affiliations Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Marc B. Bierings,

  Affiliation Department of Pediatric Hematology/Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Lydie Da Costa,

  Affiliations AP-HP, Service d'Hématologie Biologique, Hôpital Robert Debré, Paris, France, Université Paris VII-Denis Diderot, Sorbonne Paris Cité, Paris, France, U773, CRB3, Paris, France

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• Alyson W. MacInnes

  * E-mail: a.macinnes@hubrecht.eu

  Affiliation Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands

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