Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities

Tianyi Zhang; Yang Liao; Fu-Ning Hsu; Robin Zhang; Jennifer S. Searle; Xun Pei; Xuan Li; Hyung Don Ryoo; Jun-Yuan Ji; Wei Du

doi:10.1371/journal.pgen.1004357

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Open Access

Peer-reviewed

Research Article

Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities

Tianyi Zhang ,

Contributed equally to this work with: Tianyi Zhang, Yang Liao

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Yang Liao ,

Contributed equally to this work with: Tianyi Zhang, Yang Liao

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Fu-Ning Hsu,

Affiliation Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
⨯
Robin Zhang,

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jennifer S. Searle,

Current address: Richard J. Daley College, Chicago, Illinois, United States of America

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Xun Pei,

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Xuan Li,

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯
Hyung Don Ryoo,

Affiliation Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
⨯
Jun-Yuan Ji,

Affiliation Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
⨯
Wei Du

* E-mail: wei@uchicago.edu

Affiliation Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America
⨯

Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities

Tianyi Zhang,
Yang Liao,
Fu-Ning Hsu,
Robin Zhang,
Jennifer S. Searle,
Xun Pei,
Xuan Li,
Hyung Don Ryoo,
Jun-Yuan Ji,
Wei Du

Published: May 8, 2014
https://doi.org/10.1371/journal.pgen.1004357

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