Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

Hyong-Ho Cho; Francesca Cargnin; Yujin Kim; Bora Lee; Ryuk-Jun Kwon; Heejin Nam; Rongkun Shen; Anthony P. Barnes; Jae W. Lee; Seunghee Lee; Soo-Kyung Lee

doi:10.1371/journal.pgen.1004280

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Open Access

Peer-reviewed

Research Article

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

Hyong-Ho Cho,

Affiliations Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America, Department of Otolaryngology–Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Korea
⨯
Francesca Cargnin,

Affiliation Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America
⨯
Yujin Kim,

Affiliation Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America
⨯
Bora Lee,

Affiliation Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America
⨯
Ryuk-Jun Kwon,

Affiliation Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America
⨯
Heejin Nam,

Affiliation College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
⨯
Rongkun Shen,

Affiliations Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America, Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Anthony P. Barnes,

Affiliations Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America, Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Jae W. Lee,

Affiliations Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America, Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Seunghee Lee ,

* E-mail: leeseung@snu.ac.kr (SL); leesoo@ohsu.edu (SKL)

Affiliation College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
⨯
Soo-Kyung Lee

* E-mail: leeseung@snu.ac.kr (SL); leesoo@ohsu.edu (SKL)

Affiliations Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America, Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

Hyong-Ho Cho,
Francesca Cargnin,
Yujin Kim,
Bora Lee,
Ryuk-Jun Kwon,
Heejin Nam,
Rongkun Shen,
Anthony P. Barnes,
Jae W. Lee,
Seunghee Lee

Published: April 24, 2014
https://doi.org/10.1371/journal.pgen.1004280

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Cholinergics
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Spinal cord
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Gene expression
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Neurons
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Electroporation
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Interneurons
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Gene regulation
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