Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke

• Stephen R. Williams ,

  Contributed equally to this work with: Stephen R. Williams, Qiong Yang

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, United States of America

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• Qiong Yang ,

  Contributed equally to this work with: Stephen R. Williams, Qiong Yang

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America

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• Fang Chen,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Xuan Liu,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Keith L. Keene,

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America, Department of Biology, East Carolina University, Greenville, North Carolina, United States of America, Center for Health Disparities Research, East Carolina University, Greenville, North Carolina, United States of America

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• Paul Jacques,

  Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America

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• Wei-Min Chen,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Galit Weinstein,

  Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Fang-Chi Hsu,

  Affiliation Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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• Alexa Beiser,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Liewei Wang,

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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• Ebony Bookman,

  Affiliation National Human Genome Research Institute, Bethesda, Maryland, United States of America

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• Kimberly F. Doheny,

  Affiliation Center for Inherited Disease Research, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Philip A. Wolf,

  Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Michelle Zilka,

  Affiliation Center for Inherited Disease Research, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Jacob Selhub,

  Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America

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• Sarah Nelson,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Stephanie M. Gogarten,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Bradford B. Worrall ,

  ¶BBW, SS, and MMS are joint senior authors on this work.

  Affiliations Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America, Department of Neurology University of Virginia, Charlottesville, Virginia, United States of America

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• Sudha Seshadri ,

  ¶BBW, SS, and MMS are joint senior authors on this work.

  Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Michèle M. Sale ,

  * E-mail: ms5fe@eservices.virginia.edu

  ¶BBW, SS, and MMS are joint senior authors on this work.

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America

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• the Genomics and Randomized Trials Network ,

  ¶‡ Membership of the Genomics and Randomized Trials Network and the Framingham Heart Study is provided in the Acknowledgments.

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•  [ ... ],
• the Framingham Heart Study

  ¶‡ Membership of the Genomics and Randomized Trials Network and the Framingham Heart Study is provided in the Acknowledgments.

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