Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Camille A. Huser; Kathryn L. Gilroy; Jeroen de Ridder; Anna Kilbey; Gillian Borland; Nancy Mackay; Alma Jenkins; Margaret Bell; Pawel Herzyk; Louise van der Weyden; David J. Adams; Alistair G. Rust; Ewan Cameron; James C. Neil

doi:10.1371/journal.pgen.1004167

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Open Access

Peer-reviewed

Research Article

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Camille A. Huser,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Kathryn L. Gilroy,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Jeroen de Ridder,

Affiliation Delft Bioinformatics Lab, Faculty of EEMCS, TU Delft, Delft, The Netherlands
⨯
Anna Kilbey,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Gillian Borland,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Nancy Mackay,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Alma Jenkins,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Margaret Bell,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Pawel Herzyk,

Affiliation Glasgow Polyomics, Institute of Molecular, Cell & Systems Biology, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Louise van der Weyden,

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
⨯
David J. Adams,

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
⨯
Alistair G. Rust ,

* E-mail: ar12@sanger.ac.uk (AGR); James.Neil@glasgow.ac.uk (JCN)

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
⨯
Ewan Cameron,

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
James C. Neil

* E-mail: ar12@sanger.ac.uk (AGR); James.Neil@glasgow.ac.uk (JCN)

Affiliation Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Camille A. Huser,
Kathryn L. Gilroy,
Jeroen de Ridder,
Anna Kilbey,
Gillian Borland,
Nancy Mackay,
Alma Jenkins,
Margaret Bell,
Pawel Herzyk,
Louise van der Weyden

Published: February 27, 2014
https://doi.org/10.1371/journal.pgen.1004167

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