Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Tasnim Dayeh; Petr Volkov; Sofia Salö; Elin Hall; Emma Nilsson; Anders H. Olsson; Clare L. Kirkpatrick; Claes B. Wollheim; Lena Eliasson; Tina Rönn; Karl Bacos; Charlotte Ling

doi:10.1371/journal.pgen.1004160

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Open Access

Peer-reviewed

Research Article

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Tasnim Dayeh,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Petr Volkov,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Sofia Salö,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Elin Hall,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Emma Nilsson,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Anders H. Olsson,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Clare L. Kirkpatrick,

Affiliation Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
⨯
Claes B. Wollheim,

Affiliation Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
⨯
Lena Eliasson,

Affiliation Islet Cell Exocytosis, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Tina Rönn,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Karl Bacos,

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯
Charlotte Ling

* E-mail: Charlotte.ling@med.lu.se

Affiliation Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmö, Sweden
⨯

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Tasnim Dayeh,
Petr Volkov,
Sofia Salö,
Elin Hall,
Emma Nilsson,
Anders H. Olsson,
Clare L. Kirkpatrick,
Claes B. Wollheim,
Lena Eliasson,
Tina Rönn

Published: March 6, 2014
https://doi.org/10.1371/journal.pgen.1004160

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05 May 2014
10:47 GMT
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Supplementary data-Illumina 450k array data Posted by Tasnim on 05 May 2014 at 10:47 GMT

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DNA methylation
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Gene expression
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Insulin secretion
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Glucagon
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Transfection
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Type 2 diabetes
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Epigenetics
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Genome analysis
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