Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

• Hsin-Hung Chou,

  Current address: Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

  Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland

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• Nigel F. Delaney,

  Current address: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

  Affiliation Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Jeremy A. Draghi,

  Affiliations Department of Zoology, University of British Columbia, Vancouver, Canada, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Christopher J. Marx

  * E-mail: cmarx@uidaho.edu

  Current address: Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America.

  Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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