High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

• Mitja I. Kurki ,

  * E-mail: mitja.kurki@uef.fi

  Affiliations Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland, Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland, Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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• Emília Ilona Gaál,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Johannes Kettunen,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Tuuli Lappalainen,

  Affiliation Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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• Androniki Menelaou,

  Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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• Verneri Anttila,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Femke N. G. van 't Hof,

  Affiliation UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands

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• Mikael von und zu Fraunberg,

  Affiliations Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland, Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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• Seppo Helisalmi,

  Affiliation Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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• Mikko Hiltunen,

  Affiliation Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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• Hanna Lehto,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Aki Laakso,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Riku Kivisaari,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Timo Koivisto,

  Affiliation Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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• Antti Ronkainen,

  Affiliation Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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• Jaakko Rinne,

  Affiliation Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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• Lambertus A. L. Kiemeney,

  Affiliations Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Department for Health Evidence, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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• Sita H. Vermeulen,

  Affiliation Department for Health Evidence, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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• Mari A. Kaunisto,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland

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• Johan G. Eriksson,

  Affiliations Folkhälsan Research Centre, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Department of Internal Medicine, Vasa Central Hospital, Vasa, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland

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• Arpo Aromaa,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Markus Perola,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Terho Lehtimäki,

  Affiliation Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere, Tampere, Finland

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• Olli T. Raitakari,

  Affiliations Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Central Hospital, Turku, Finland

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• Veikko Salomaa,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Murat Gunel,

  Affiliation Department of Neurosurgery, Department of Neurobiology and Department of Genetics, Program on Neurogenetics, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Emmanouil T. Dermitzakis,

  Affiliation Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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• Ynte M. Ruigrok,

  Affiliation UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands

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• Gabriel J. E. Rinkel,

  Affiliation UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands

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• Mika Niemelä,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Juha Hernesniemi,

  Affiliation Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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• Samuli Ripatti,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Hjelt Institute, University of Helsinki, Helsinki, Finland

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• Paul I. W. de Bakker,

  Affiliations Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

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• Aarno Palotie ,

  ¶These authors jointly directed this work.

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Human Genetics, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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•  [ ... ],
• Juha E. Jääskeläinen

  ¶These authors jointly directed this work.

  Affiliations Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland, Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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