Genetic Models of Apoptosis-Induced Proliferation Decipher Activation of JNK and Identify a Requirement of EGFR Signaling for Tissue Regenerative Responses in Drosophila

Yun Fan; Shiuan Wang; Jacob Hernandez; Vildan Betul Yenigun; Gillian Hertlein; Caitlin E. Fogarty; Jillian L. Lindblad; Andreas Bergmann

doi:10.1371/journal.pgen.1004131

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Peer-reviewed

Research Article

Genetic Models of Apoptosis-Induced Proliferation Decipher Activation of JNK and Identify a Requirement of EGFR Signaling for Tissue Regenerative Responses in Drosophila

Yun Fan ,

* E-mail: y.fan@bham.ac.uk (YF); andreas.bergmann@umassmed.edu (AB)

Current address: School of Biosciences, University of Birmingham, Birmingham, United Kingdom.

Affiliation University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America
⨯
Shiuan Wang,

Affiliation Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jacob Hernandez,

Affiliation MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Houston, Texas, United States of America
⨯
Vildan Betul Yenigun,

Affiliation MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Houston, Texas, United States of America
⨯
Gillian Hertlein,

Affiliation Länderinstitut für Bienenkunde, Humboldt Universität zu Berlin, Hohen Neuendorf, Germany
⨯
Caitlin E. Fogarty,

Affiliation University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America
⨯
Jillian L. Lindblad,

Affiliation University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America
⨯
Andreas Bergmann

* E-mail: y.fan@bham.ac.uk (YF); andreas.bergmann@umassmed.edu (AB)

Affiliations University of Massachusetts Medical School, Department of Cancer Biology, Worcester, Massachusetts, United States of America, Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Houston, Texas, United States of America
⨯

Genetic Models of Apoptosis-Induced Proliferation Decipher Activation of JNK and Identify a Requirement of EGFR Signaling for Tissue Regenerative Responses in Drosophila

Yun Fan,
Shiuan Wang,
Jacob Hernandez,
Vildan Betul Yenigun,
Gillian Hertlein,
Caitlin E. Fogarty,
Jillian L. Lindblad,
Andreas Bergmann

Published: January 30, 2014
https://doi.org/10.1371/journal.pgen.1004131

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Apoptosis
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Eyes
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RNA interference
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Genetic screens
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c-Jun N-terminal kinase signaling cascade
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Imaginal discs
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EGFR signaling
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Drosophila melanogaster
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