Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease

• Marco Medici ,

  Contributed equally to this work with: Marco Medici, Eleonora Porcu, Giorgio Pistis

  * E-mail: m.medici@erasmusmc.nl

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Eleonora Porcu ,

  Contributed equally to this work with: Marco Medici, Eleonora Porcu, Giorgio Pistis

  Affiliations Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy, Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy

  ⨯
• Giorgio Pistis ,

  Contributed equally to this work with: Marco Medici, Eleonora Porcu, Giorgio Pistis

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Alexander Teumer,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

  ⨯
• Suzanne J. Brown,

  Affiliation Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

  ⨯
• Richard A. Jensen,

  Affiliation Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America

  ⨯
• Rajesh Rawal,

  Affiliation Institute for Genetic Epidemiology, Helmholtz Zentrum Munich, Munich/Neuherberg, Germany

  ⨯
• Greet L. Roef,

  Affiliation Department of Endocrinology and Internal Medicine, University Hospital Ghent and Faculty of Medicine, Ghent University, Ghent, Belgium

  ⨯
• Theo S. Plantinga,

  Affiliation Internal Medicine, Division of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Sita H. Vermeulen,

  Affiliation Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

  ⨯
• Jari Lahti,

  Affiliation Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

  ⨯
• Matthew J. Simmonds,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Oxford, UK Churchill Hospital, Headington, Oxford, United Kingdom

  ⨯
• Lise Lotte N. Husemoen,

  Affiliation Research Centre for Prevention and Health, Glostrup University Hospital, the Capital Region of Denmark, Glostrup, Denmark

  ⨯
• Rachel M. Freathy,

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Beverley M. Shields,

  Affiliation Peninsula NIHR Clinical Research Facility, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Diana Pietzner,

  Affiliation Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany

  ⨯
• Rebecca Nagy,

  Affiliation Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  ⨯
• Linda Broer,

  Affiliation Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Layal Chaker,

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Tim I. M. Korevaar,

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Maria Grazia Plia,

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
• Cinzia Sala,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Uwe Völker,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

  ⨯
• J. Brent Richards,

  Affiliations Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Montreal, Canada, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Fred C. Sweep,

  Affiliation Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

  ⨯
• Christian Gieger,

  Affiliation Institute for Genetic Epidemiology, Helmholtz Zentrum Munich, Munich/Neuherberg, Germany

  ⨯
• Tanguy Corre,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Eero Kajantie,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

  ⨯
• Betina Thuesen,

  Affiliation Research Centre for Prevention and Health, Glostrup University Hospital, the Capital Region of Denmark, Glostrup, Denmark

  ⨯
• Youri E. Taes,

  Affiliation Department of Endocrinology and Internal Medicine, University Hospital Ghent and Faculty of Medicine, Ghent University, Ghent, Belgium

  ⨯
• W. Edward Visser,

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Andrew T. Hattersley,

  Affiliation Peninsula NIHR Clinical Research Facility, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Jürgen Kratzsch,

  Affiliation Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Alexander Hamilton,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Oxford, UK Churchill Hospital, Headington, Oxford, United Kingdom

  ⨯
• Wei Li,

  Affiliation Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  ⨯
• Georg Homuth,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

  ⨯
• Monia Lobina,

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
• Stefano Mariotti,

  Affiliation Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy

  ⨯
• Nicole Soranzo,

  Affiliation Wellcome Trust Sanger Institute, Hixton, United Kingdom

  ⨯
• Massimiliano Cocca,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Matthias Nauck,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Christin Spielhagen,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Alec Ross,

  Affiliation Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

  ⨯
• Alice Arnold,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

  ⨯
• Martijn van de Bunt,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Oxford, UK Churchill Hospital, Headington, Oxford, United Kingdom

  ⨯
• Sandya Liyanarachchi,

  Affiliation Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  ⨯
• Margit Heier,

  Affiliation Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany

  ⨯
• Hans Jörgen Grabe,

  Affiliation Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Greifswald, Germany

  ⨯
• Corrado Masciullo,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Tessel E. Galesloot,

  Affiliation Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

  ⨯
• Ee M. Lim,

  Affiliation Pathwest Laboratory Medicine WA, Nedlands, Western Australia, Australia

  ⨯
• Eva Reischl,

  Affiliation Research Unit of Molecular Epidemiology Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Peter J. Leedman,

  Affiliations School of Medicine and Pharmacology, the University of Western Australia, Crawley, Western Australia, Australia, UWA Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia, Australia

  ⨯
• Sandra Lai,

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
• Alessandro Delitala,

  Affiliation Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy

  ⨯
• Alexandra P. Bremner,

  Affiliation School of Population Health, University of Western Australia, Nedlands, Western Australia, Australia

  ⨯
• David I. W. Philips,

  Affiliation MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom

  ⨯
• John P. Beilby,

  Affiliations Pathwest Laboratory Medicine WA, Nedlands, Western Australia, Australia, School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia

  ⨯
• Antonella Mulas,

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
• Matteo Vocale,

  Affiliation High Performance Computing and Network, CRS4, Parco Tecnologico della Sardegna, Pula, Italy

  ⨯
• Goncalo Abecasis,

  Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Tom Forsen,

  Affiliations Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Vaasa Health Care Centre, Diabetes Unit, Vaasa, Finland

  ⨯
• Alan James,

  Affiliations School of Medicine and Pharmacology, the University of Western Australia, Crawley, Western Australia, Australia, Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

  ⨯
• Elisabeth Widen,

  Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

  ⨯
• Jennie Hui,

  Affiliation Pathwest Laboratory Medicine WA, Nedlands, Western Australia, Australia

  ⨯
• Holger Prokisch,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum Munich, Munich, Germany, Institute of Human Genetics, Technische Universität München, Munich, Germany

  ⨯
• Ernst E. Rietzschel,

  Affiliation Department of Cardiology and Internal Medicine, University Hospital Ghent and Faculty of Medicine, Ghent University, Ghent, Belgium

  ⨯
• Aarno Palotie,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

  ⨯
• Peter Feddema,

  Affiliation Diagnostica Stago, Doncaster, Victoria, Australia

  ⨯
• Stephen J. Fletcher,

  Affiliation Pathwest Laboratory Medicine WA, Nedlands, Western Australia, Australia

  ⨯
• Katharina Schramm,

  Affiliation Institute of Human Genetics, Helmholtz Zentrum Munich, Munich, Germany

  ⨯
• Jerome I. Rotter,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, California, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

  ⨯
• Alexander Kluttig,

  Affiliation Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany

  ⨯
• Dörte Radke,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Michela Traglia,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy

  ⨯
• Gabriela L. Surdulescu,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Huiling He,

  Affiliation Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  ⨯
• Jayne A. Franklyn,

  Affiliation School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Univeristy of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Daniel Tiller,

  Affiliation Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany

  ⨯
• Bijay Vaidya,

  Affiliation Diabetes, Endocrinology and Vascular Health Centre, Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom

  ⨯
• Tim de Meyer,

  Affiliation BIOBIX Lab. for Bioinformatics and Computational Genomics, Dept. of Mathematical Modelling, Statistics and Bioinformatics. Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium

  ⨯
• Torben Jørgensen,

  Affiliations Research Centre for Prevention and Health, Glostrup University Hospital, the Capital Region of Denmark, Glostrup, Denmark, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

  ⨯
• Johan G. Eriksson,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland, Folkhalsan Research Centre, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland

  ⨯
• Peter C. O'Leary,

  Affiliations School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia, Curtin Health Innovation Research Institute, Curtin University of Technology, Bentley, Western Australia, Australia

  ⨯
• Eric Wichmann,

  Affiliation Institute of Epidemiology I, Helmholtz Zentrum Munich, Munich, Germany

  ⨯
• Ad R. Hermus,

  Affiliation Internal Medicine, Division of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

  ⨯
• Till Ittermann,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Emanuele Bosi,

  Affiliation Department of Internal Medicine, Diabetes & Endocrinology Unit, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy

  ⨯
• David Schlessinger,

  Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

  ⨯
• Henri Wallaschofski,

  Affiliation Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Nicola Pirastu,

  Affiliations Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste, Italy, University of Trieste, Trieste, Italy

  ⨯
• Yurii S. Aulchenko,

  Affiliation Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Albert de la Chapelle,

  Affiliation Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  ⨯
• Romana T. Netea-Maier,

  Affiliation Internal Medicine, Division of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Stephen C. L. Gough,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Oxford, UK Churchill Hospital, Headington, Oxford, United Kingdom

  ⨯
• Henriette Meyer zu Schwabedissen,

  Affiliation Biopharmacy, Department of Pharmaceutical Sciences, University Basel, Basel, Switzerland

  ⨯
• Timothy M. Frayling,

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Jean-Marc Kaufman,

  Affiliation Department of Endocrinology and Internal Medicine, University Hospital Ghent and Faculty of Medicine, Ghent University, Ghent, Belgium

  ⨯
• Allan Linneberg,

  Affiliation Research Centre for Prevention and Health, Glostrup University Hospital, the Capital Region of Denmark, Glostrup, Denmark

  ⨯
• Katri Räikkönen,

  Affiliation Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland

  ⨯
• Johannes W. A. Smit,

  Affiliation Internal Medicine, Division of Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Lambertus A. Kiemeney,

  Affiliation Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

  ⨯
• John P. Walsh,

  Affiliations Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia, School of Medicine and Pharmacology, the University of Western Australia, Crawley, Western Australia, Australia

  ⨯
• Christa Meisinger,

  Affiliation Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany

  ⨯
• Martin den Heijer,

  Affiliation Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands

  ⨯
• Theo J. Visser,

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Timothy D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Scott G. Wilson,

  Affiliations Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia, School of Medicine and Pharmacology, the University of Western Australia, Crawley, Western Australia, Australia, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Anne Cappola,

  Affiliation Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Daniela Toniolo,

  Affiliations Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy, Institute of Molecular Genetics-CNR, Pavia, Italy

  ⨯
• Serena Sanna ,

  ¶SS, SN and RPP also contributed equally to this work.

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
• Silvia Naitza ,

  ¶SS, SN and RPP also contributed equally to this work.

  Affiliation Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

  ⨯
•  [ ... ],
• Robin P. Peeters

  ¶SS, SN and RPP also contributed equally to this work.

  Affiliation Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

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