Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

• Indroneal Banerjee,

  Affiliation Department of Medicine, University of California-San Diego, La Jolla, California, United States of America

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• Jianlin Zhang,

  Affiliation Department of Medicine, University of California-San Diego, La Jolla, California, United States of America

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• Thomas Moore-Morris,

  Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California, United States of America

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• Emily Pfeiffer,

  Affiliation Department of Bioengineering, University of California-San Diego, La Jolla, California, United States of America

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• Kyle S. Buchholz,

  Affiliation Department of Bioengineering, University of California-San Diego, La Jolla, California, United States of America

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• Ao Liu,

  Affiliation Department of Medicine, University of California-San Diego, La Jolla, California, United States of America

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• Kunfu Ouyang,

  Affiliations Department of Medicine, University of California-San Diego, La Jolla, California, United States of America, Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China

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• Matthew J. Stroud,

  Affiliation Department of Medicine, University of California-San Diego, La Jolla, California, United States of America

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• Larry Gerace,

  Affiliation Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Sylvia M. Evans,

  Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California, United States of America

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• Andrew McCulloch,

  Affiliations Department of Medicine, University of California-San Diego, La Jolla, California, United States of America, Department of Bioengineering, University of California-San Diego, La Jolla, California, United States of America

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• Ju Chen

  * E-mail: juchen@ucsd.edu

  Affiliation Department of Medicine, University of California-San Diego, La Jolla, California, United States of America

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