C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

Marie S. Hasemann; Felicia K. B. Lauridsen; Johannes Waage; Janus S. Jakobsen; Anne-Katrine Frank; Mikkel B. Schuster; Nicolas Rapin; Frederik O. Bagger; Philipp S. Hoppe; Timm Schroeder; Bo T. Porse

doi:10.1371/journal.pgen.1004079

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Peer-reviewed

Research Article

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

Marie S. Hasemann,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Felicia K. B. Lauridsen,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Johannes Waage,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Janus S. Jakobsen,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Anne-Katrine Frank,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Mikkel B. Schuster,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Nicolas Rapin,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Frederik O. Bagger,

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Philipp S. Hoppe,

Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
⨯
Timm Schroeder,

Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
⨯
Bo T. Porse

* E-mail: bo.porse@finsenlab.dk

Affiliations The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark, Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, The Bioinformatic Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

Marie S. Hasemann,
Felicia K. B. Lauridsen,
Johannes Waage,
Janus S. Jakobsen,
Anne-Katrine Frank,
Mikkel B. Schuster,
Nicolas Rapin,
Frederik O. Bagger,
Philipp S. Hoppe,
Timm Schroeder

Published: January 9, 2014
https://doi.org/10.1371/journal.pgen.1004079

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