Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

Open Access

Peer-reviewed

Research Article

Jamie T. Bridgham,

Affiliation Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America
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June Keay,

Affiliation Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America
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Eric A. Ortlund,

Affiliation Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America
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Joseph W. Thornton

* E-mail: joet1@uchicago.edu

Affiliations Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America, Departments of Human Genetics and Ecology & Evolution, The University of Chicago, Chicago, Illinois, United States of America
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Evolutionary genetics
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Molecular evolution
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Substitution mutation
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Allosteric regulation
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Evolutionary biology
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Phylogenetics
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Estrogens
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Transcription factors
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