TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

Annabel A. Ferguson; Sudipa Roy; Kaitlyn N. Kormanik; Yongsoon Kim; Kathleen J. Dumas; Vladimir B. Ritov; Dietrich Matern; Patrick J. Hu; Alfred L. Fisher

doi:10.1371/journal.pgen.1004020

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Peer-reviewed

Research Article

TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

Annabel A. Ferguson,

Affiliation Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Sudipa Roy ,

Contributed equally to this work with: Sudipa Roy, Kaitlyn N. Kormanik, Yongsoon Kim

Affiliations Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Center for Healthy Aging, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Kaitlyn N. Kormanik ,

Contributed equally to this work with: Sudipa Roy, Kaitlyn N. Kormanik, Yongsoon Kim

Affiliation Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Yongsoon Kim ,

Contributed equally to this work with: Sudipa Roy, Kaitlyn N. Kormanik, Yongsoon Kim

Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Kathleen J. Dumas,

Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Vladimir B. Ritov,

Affiliation Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Dietrich Matern,

Affiliation Biochemical Genetics Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Patrick J. Hu,

Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Alfred L. Fisher

* E-mail: fishera2@uthscsa.edu

Affiliations Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Center for Healthy Aging, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, GRECC, South Texas VA Health Care System, San Antonio, Texas, United States of America
⨯

TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

Annabel A. Ferguson,
Sudipa Roy,
Kaitlyn N. Kormanik,
Yongsoon Kim,
Kathleen J. Dumas,
Vladimir B. Ritov,
Dietrich Matern,
Patrick J. Hu,
Alfred L. Fisher

Published: December 19, 2013
https://doi.org/10.1371/journal.pgen.1004020

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23 Jan 2014
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L-tyrosine as a bioregulator Posted by aslominski on 27 Dec 2013 at 21:03 GMT

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Tyrosine
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RNA interference
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Gene expression
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Aminotransferases
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Larvae
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Protein kinase signaling cascade
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