A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Michael A. Kennedy; Kenneth Gable; Karolina Niewola-Staszkowska; Susana Abreu; Anne Johnston; Linda J. Harris; Fulvio Reggiori; Robbie Loewith; Teresa Dunn; Steffany A. L. Bennett; Kristin Baetz

doi:10.1371/journal.pgen.1004010

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Open Access

Peer-reviewed

Research Article

A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Michael A. Kennedy,

Affiliation Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
⨯
Kenneth Gable,

Affiliation Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Karolina Niewola-Staszkowska,

Affiliation Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva, Switzerland
⨯
Susana Abreu,

Affiliation Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Anne Johnston,

Affiliation Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada
⨯
Linda J. Harris,

Affiliation Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada
⨯
Fulvio Reggiori,

Affiliation Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Robbie Loewith,

Affiliation Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva, Switzerland
⨯
Teresa Dunn,

Affiliation Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Steffany A. L. Bennett,

Affiliation Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
⨯
Kristin Baetz

* E-mail: kbaetz@uottawa.ca

Affiliation Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
⨯

A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Michael A. Kennedy,
Kenneth Gable,
Karolina Niewola-Staszkowska,
Susana Abreu,
Anne Johnston,
Linda J. Harris,
Fulvio Reggiori,
Robbie Loewith,
Teresa Dunn,
Steffany A. L. Bennett

Published: January 23, 2014
https://doi.org/10.1371/journal.pgen.1004010

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Sphingolipids
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Lipids
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Phosphorylation
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Signal inhibition
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Saccharomyces cerevisiae
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TOR signaling
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Lipid signaling
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