Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

Hannes Olauson; Karolina Lindberg; Risul Amin; Tadatoshi Sato; Ting Jia; Regina Goetz; Moosa Mohammadi; Göran Andersson; Beate Lanske; Tobias E. Larsson

doi:10.1371/journal.pgen.1003975

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Open Access

Peer-reviewed

Research Article

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

Hannes Olauson,

Affiliation Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
⨯
Karolina Lindberg,

Affiliation Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
⨯
Risul Amin,

Affiliation Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
⨯
Tadatoshi Sato,

Affiliation Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
⨯
Ting Jia,

Affiliation Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
⨯
Regina Goetz,

Affiliation Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America
⨯
Moosa Mohammadi,

Affiliation Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America
⨯
Göran Andersson,

Affiliation Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Beate Lanske,

Affiliation Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
⨯
Tobias E. Larsson

* E-mail: tobias.larsson@ki.se

Affiliations Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, Department of Nephrology, Karolinska University Hospital, Stockholm, Sweden
⨯

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

Hannes Olauson,
Karolina Lindberg,
Risul Amin,
Tadatoshi Sato,
Ting Jia,
Regina Goetz,
Moosa Mohammadi,
Göran Andersson,
Beate Lanske,
Tobias E. Larsson

Published: December 12, 2013
https://doi.org/10.1371/journal.pgen.1003975

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Parathyroid
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Secretion
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Parathyroid hormone
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Fibroblast growth factor
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Calcineurin signaling cascade
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Mouse models
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Renal failure
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